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Solomon G. Diamond

Associate Professor of Engineering

Co-Director, Design Initiative at Dartmouth

+1 (603) 646-1311

solomon.g.diamond@dartmouth.edu

Professor Diamond discusses the Design Initiative at Dartmouth.

Research Interests

Biomedical imaging; functional neuroimaging; magnetic nanoparticle imaging

Education

AB, Engineering Sciences, Dartmouth 1997
BE, Engineering Sciences, Dartmouth 1998
SM, Engineering Sciences, Harvard 2001
PhD, Engineering Sciences, Harvard 2004

Awards

Outstanding Service Award for Faculty, 2023
Derek Bok Award for Distinction in Teaching, Harvard, 2002

Professional Activities

Member, IEEE
Member, Tau Beta Pi

Startups

Lodestone Biomedical
Co-Founder

Research Projects

Magnetic nanoparticle imaging

Magnetic nanoparticle imaging

Magnetic nanoparticle imaging is being developed to meet the needs of translational research on the biodistribution of magnetic nanoparticles (MNPs). Emerging nanotechnology platforms promise to deliver new tools to detect, monitor and treat cancer. These nanotechnology platforms offer a future of personalized medicine where a nanocarrier can be targeted to specific cancer cells, carry a drug payload, be remotely activated at a specific location in the body or upon targeted binding to selected cell types, imaged in-real time, and monitored as therapy progresses. Among the many nanocarriers in development, those utilizing MNPs are ideally suited for translational research because of their long history in biomedical research and many practical applications. We have developed an MNP imaging method called nonlinear susceptibility magnitude imaging (nSMI). Our imaging system has the potential for broad use in translational MNP research because of its functional and cost-efficient design.
Clinical optical-electric probes

Clinical optical-electric probes

Clinical optical-electric probes are being developed for noninvasive simultaneous measurement of blood oxygenation and electrical potential changes associated with brain activity.
Neurovascular coupling

Neurovascular coupling

Neurovascular coupling refers to the mechanisms that relate evoked neural activity to localized responses by the cerebral vasculature. Better models of this coupling are needed to improve the interpretation of neuroimaging studies and understanding of neurodegenerative disease.

Selected Publications

Ficko, B.W., NDong, C., Giacometti, P., Griswold, K.E., & Diamond, S.G. (2017). A feasibility study of nonlinear spectroscopic measurement of magnetic nanoparticles targeted to cancer cells. IEEE Transactions on Biomedical Engineering, vol. 64, no. 5, pp. 972–979.
Ficko, B.W., Liebl, M., Knopke, C., Phan, M. Q., Steinhoff, U., Frank Wiekhorst F., & Diamond, S.G. (2016) Nonlinear spectroscopic characterization and Volterra series modeling of magnetic nanoparticles. IEEE Transactions on Magnetics, 53(2), 1–12.
Ficko, B.W., Giacometti, P., Diamond, S.G. (2015). Extended Arrays for Nonlinear Susceptibility Magnitude Imaging. Biomedical Engineering/Biomedizinische Technik, 60(5), 457–463.
Ficko, B.W., Giacometti, P., Diamond, S.G. (2015) Nonlinear susceptibility magnitude imaging of magnetic nanoparticles. Journal of Magnetism and Magnetic Materials, 378(C), 267–277.
Ficko, B.W., Nadar, P.M., Diamond, S.G. (2015) Spectroscopic AC susceptibility imaging (sASI) of magnetic nanoparticles. Journal of Magnetism and Magnetic Materials, 375(C), 164–176.
Ficko, B.W., Nadar, P.M., Hoopes, P.J., Diamond, S.G. (2014) Development of a magnetic nanoparticle susceptibility magnitude imaging array. Phys. Med. Biol. 59(4):1047-1071.
Giacometti, P., Diamond, S.G. (2014). Correspondence of electroencephalography and near-infrared spectroscopy sensitivities to the cerebral cortex using a high-density layout. Neurophotonics, 1(2), 025001–025001.
Giacometti, P., Perdue, K.L., Diamond, S.G. (2014) Algorithm to find high density EEG scalp coordinates and analysis of their correspondence to structural and functional regions of the brain. J Neurosci Methods. 229:84-96.
Perdue, K.L., Diamond, S.G. (2014) T1 magnetic resonance imaging head segmentation for diffuse optical tomography and electroencephalography. J. Biomed. Opt. 19(2):026011.
Ficko, B.W., Nadar, P.M., Hoopes, P.J., Diamond, S.G. (2014) Development of a magnetic nanoparticle susceptibility magnitude imaging array. Phys. Med. Biol. 59(4):1047-1071.
Perdue, K.L., Diamond, S.G. (2013) Effects of spatial pattern scale of brain activity on the sensitivity of DOT, fMRI, EEG and MEG. PLoS ONE 8(12):e83299.
Talukdar, T., Moore, J.H., Diamond, S.G. (2013) Continuous correction of differential path length factor in near-infrared spectroscopy. J. Biomed. Opt. 18(5), 056001.

Patents

Method and apparatus for magnetic susceptibility tomography, magnetoencephalography, and taggant or contrast agent detection | 9,395,425
System and methods for smoothly inverting one or more faces of a cubical device | 8,753,029
System, optode and cap for near-infrared diffuse-optical function neuroimaging | 8,527,035
In-bed exercise machine and method of use | 6,270,445
In-bed exercise machine and method of use | 6,152,855